Developing mitochondrial base editors with diverse context compatibility and high fidelity via satur...
Developing mitochondrial base editors with diverse context compatibility and high fidelity via saturated spacer library
About this item
Full title
Author / Creator
Sun, Haifeng , Wang, Zhaojun , Shen, Limini , Feng, Yeling , Han, Lu , Qian, Xuezhen , Meng, Runde , Ji, Kangming , Liang, Dong , Zhou, Fei , Lou, Xin , Zhang, Jun and Shen, Bin
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
Formats
Publication information
Publisher
London: Nature Publishing Group UK
Subjects
More information
Scope and Contents
Contents
DddA-derived cytosine base editors (DdCBEs) greatly facilitated the basic and therapeutic research of mitochondrial DNA mutation diseases. Here we devise a saturated spacer library and successfully identify seven DddA homologs by performing high-throughput sequencing based screen. DddAs of
Streptomyces
sp.
BK438
and
Lachnospiraceae b...
Alternative Titles
Full title
Developing mitochondrial base editors with diverse context compatibility and high fidelity via saturated spacer library
Authors, Artists and Contributors
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Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_8f7a3de5074c4acf975f0b96a03f0a19
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_8f7a3de5074c4acf975f0b96a03f0a19
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-023-42359-3
