Dynamics of GLP-1R peptide agonist engagement are correlated with kinetics of G protein activation
Dynamics of GLP-1R peptide agonist engagement are correlated with kinetics of G protein activation
About this item
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Author / Creator
Deganutti, Giuseppe , Liang, Yi-Lynn , Zhang, Xin , Khoshouei, Maryam , Clydesdale, Lachlan , Belousoff, Matthew J. , Venugopal, Hari , Truong, Tin T. , Glukhova, Alisa , Keller, Andrew N. , Gregory, Karen J. , Leach, Katie , Christopoulos, Arthur , Danev, Radostin , Reynolds, Christopher A. , Zhao, Peishen , Sexton, Patrick M. and Wootten, Denise
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publication information
Publisher
London: Nature Publishing Group UK
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Scope and Contents
Contents
The glucagon-like peptide-1 receptor (GLP-1R) has broad physiological roles and is a validated target for treatment of metabolic disorders. Despite recent advances in GLP-1R structure elucidation, detailed mechanistic understanding of how different peptides generate profound differences in G protein-mediated signalling is still lacking. Here we com...
Alternative Titles
Full title
Dynamics of GLP-1R peptide agonist engagement are correlated with kinetics of G protein activation
Authors, Artists and Contributors
Author / Creator
Liang, Yi-Lynn
Zhang, Xin
Khoshouei, Maryam
Clydesdale, Lachlan
Belousoff, Matthew J.
Venugopal, Hari
Truong, Tin T.
Glukhova, Alisa
Keller, Andrew N.
Gregory, Karen J.
Leach, Katie
Christopoulos, Arthur
Danev, Radostin
Reynolds, Christopher A.
Zhao, Peishen
Sexton, Patrick M.
Wootten, Denise
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Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_8f7e8894b23a4f8eb32f5d2c26ccefc6
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_8f7e8894b23a4f8eb32f5d2c26ccefc6
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-021-27760-0
