Optimization of Cas9 RNA sequence to reduce its unexpected effects as a microRNA sponge
Optimization of Cas9 RNA sequence to reduce its unexpected effects as a microRNA sponge
About this item
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Author / Creator
Jiang, Junfeng , Zeng, Tao , Zhang, Li , Fan, Xingfei , Jin, Qishu , Ni, Haitao , Ye, Yusheng , Cheng, Lipeng , Li, Li , Wang, Liujun , Xu, Sha , Yang, Yu , Gu, Juan , Guo, Bing , Wang, Lei , Li, Xin , Qin, Yingyi , Li, Jiaxi , Wang, Jinjiang , Chen, Xi , Wu, Minjuan , Ying, Qi-long , Qin, Xingjun , Wang, Yefei and Wang, Yue
Publisher
London: BioMed Central
Journal title
Language
English
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Publication information
Publisher
London: BioMed Central
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More information
Scope and Contents
Contents
Section Highlights Cas9 RNA functions as a miRNA sponge. Let-7 is the dominant regulated miRNA by Cas9 RNA. RNA sequence optimization of Cas9 by synonymous mutation improves its safety.
Alternative Titles
Full title
Optimization of Cas9 RNA sequence to reduce its unexpected effects as a microRNA sponge
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Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_8fe7ac32766e436bb70ab060b5e9d6e8
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_8fe7ac32766e436bb70ab060b5e9d6e8
Other Identifiers
ISSN
1476-4598
E-ISSN
1476-4598
DOI
10.1186/s12943-022-01604-x
