Structural basis for the non-self RNA-activated protease activity of the type III-E CRISPR nuclease-...
Structural basis for the non-self RNA-activated protease activity of the type III-E CRISPR nuclease-protease Craspase
About this item
Full title
Author / Creator
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
Formats
Publication information
Publisher
London: Nature Publishing Group UK
Subjects
More information
Scope and Contents
Contents
The RNA-targeting type III-E CRISPR-gRAMP effector interacts with a caspase-like protease TPR-CHAT to form the CRISPR-guided caspase complex (Craspase), but their functional mechanism is unknown. Here, we report cryo-EM structures of the type III-E gRAMP
crRNA
and gRAMP
crRNA
-TPR-CHAT complexes, before and after either self or non-self...
Alternative Titles
Full title
Structural basis for the non-self RNA-activated protease activity of the type III-E CRISPR nuclease-protease Craspase
Authors, Artists and Contributors
Author / Creator
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_90cc95d009f44d7da4d983e6b89696ae
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_90cc95d009f44d7da4d983e6b89696ae
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-022-35275-5
