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Functional dissection of two amino acid substitutions unique to the human FOXP2 protein

Functional dissection of two amino acid substitutions unique to the human FOXP2 protein

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_90d07661dfb049bfa545986184b8c1d4

Functional dissection of two amino acid substitutions unique to the human FOXP2 protein

About this item

Full title

Functional dissection of two amino acid substitutions unique to the human FOXP2 protein

Publisher

London: Nature Publishing Group UK

Journal title

Scientific reports, 2023-03, Vol.13 (1), p.3747-3747, Article 3747

Language

English

Formats

Publication information

Publisher

London: Nature Publishing Group UK

More information

Scope and Contents

Contents

The transcription factor forkhead box P2 (FOXP2) is involved in the development of language and speech in humans. Two amino acid substitutions (T303N, N325S) occurred in the human FOXP2 after the divergence from the chimpanzee lineage. It has previously been shown that when they are introduced into the FOXP2 protein of mice they alter striatal syna...

Alternative Titles

Full title

Functional dissection of two amino acid substitutions unique to the human FOXP2 protein

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_doaj_primary_oai_doaj_org_article_90d07661dfb049bfa545986184b8c1d4

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_90d07661dfb049bfa545986184b8c1d4

Other Identifiers

ISSN

2045-2322

E-ISSN

2045-2322

DOI

10.1038/s41598-023-30663-3

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