Neuronal hyperactivity due to loss of inhibitory tone in APOE4 mice lacking Alzheimer’s disease-like...
Neuronal hyperactivity due to loss of inhibitory tone in APOE4 mice lacking Alzheimer’s disease-like pathology
About this item
Full title
Author / Creator
Nuriel, Tal , Angulo, Sergio L. , Khan, Usman , Ashok, Archana , Chen, Qiuying , Figueroa, Helen Y. , Emrani, Sheina , Liu, Li , Herman, Mathieu , Barrett, Geoffrey , Savage, Valerie , Buitrago, Luna , Cepeda-Prado, Efrain , Fung, Christine , Goldberg, Eliana , Gross, Steven S. , Hussaini, S. Abid , Moreno, Herman , Small, Scott A. and Duff, Karen E.
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publication information
Publisher
London: Nature Publishing Group UK
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More information
Scope and Contents
Contents
The ε4 allele of apolipoprotein E (
APOE
) is the dominant genetic risk factor for late-onset Alzheimer’s disease (AD). However, the reason
APOE4
is associated with increased AD risk remains a source of debate. Neuronal hyperactivity is an early phenotype in both AD mouse models and in human AD, which may play a direct role in the patho...
Alternative Titles
Full title
Neuronal hyperactivity due to loss of inhibitory tone in APOE4 mice lacking Alzheimer’s disease-like pathology
Authors, Artists and Contributors
Author / Creator
Angulo, Sergio L.
Khan, Usman
Ashok, Archana
Chen, Qiuying
Figueroa, Helen Y.
Emrani, Sheina
Liu, Li
Herman, Mathieu
Barrett, Geoffrey
Savage, Valerie
Buitrago, Luna
Cepeda-Prado, Efrain
Fung, Christine
Goldberg, Eliana
Gross, Steven S.
Hussaini, S. Abid
Moreno, Herman
Small, Scott A.
Duff, Karen E.
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Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_91098ce8e7d943429a161e6bc0ddcf3e
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_91098ce8e7d943429a161e6bc0ddcf3e
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-017-01444-0
