The genetic architecture of age-related hearing impairment revealed by genome-wide association analy...
The genetic architecture of age-related hearing impairment revealed by genome-wide association analysis
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Author / Creator
Ivarsdottir, Erna V. , Holm, Hilma , Benonisdottir, Stefania , Olafsdottir, Thorhildur , Sveinbjornsson, Gardar , Thorleifsson, Gudmar , Eggertsson, Hannes P. , Halldorsson, Gisli H. , Hjorleifsson, Kristjan E. , Melsted, Pall , Gylfason, Arnaldur , Arnadottir, Gudny A. , Oddsson, Asmundur , Jensson, Brynjar O. , Jonasdottir, Aslaug , Jonasdottir, Adalbjorg , Juliusdottir, Thorhildur , Stefansdottir, Lilja , Tragante, Vinicius , Halldorsson, Bjarni V. , Petersen, Hannes , Thorgeirsson, Gudmundur , Thorsteinsdottir, Unnur , Sulem, Patrick , Hinriksdottir, Ingibjorg , Jonsdottir, Ingileif , Gudbjartsson, Daniel F. and Stefansson, Kari
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publication information
Publisher
London: Nature Publishing Group UK
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Contents
Age-related hearing impairment (ARHI) is the most common sensory disorder in older adults. We conducted a genome-wide association meta-analysis of 121,934 ARHI cases and 591,699 controls from Iceland and the UK. We identified 21 novel sequence variants, of which 13 are rare, under either additive or recessive models. Of special interest are a misse...
Alternative Titles
Full title
The genetic architecture of age-related hearing impairment revealed by genome-wide association analysis
Authors, Artists and Contributors
Author / Creator
Holm, Hilma
Benonisdottir, Stefania
Olafsdottir, Thorhildur
Sveinbjornsson, Gardar
Thorleifsson, Gudmar
Eggertsson, Hannes P.
Halldorsson, Gisli H.
Hjorleifsson, Kristjan E.
Melsted, Pall
Gylfason, Arnaldur
Arnadottir, Gudny A.
Oddsson, Asmundur
Jensson, Brynjar O.
Jonasdottir, Aslaug
Jonasdottir, Adalbjorg
Juliusdottir, Thorhildur
Stefansdottir, Lilja
Tragante, Vinicius
Halldorsson, Bjarni V.
Petersen, Hannes
Thorgeirsson, Gudmundur
Thorsteinsdottir, Unnur
Sulem, Patrick
Hinriksdottir, Ingibjorg
Jonsdottir, Ingileif
Gudbjartsson, Daniel F.
Stefansson, Kari
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Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_91335cb2943443128986683d51832e1d
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_91335cb2943443128986683d51832e1d
Other Identifiers
ISSN
2399-3642
E-ISSN
2399-3642
DOI
10.1038/s42003-021-02224-9
