Partial Reversal of Tissue Calcification and Extension of Life Span following Ammonium Nitrate Treat...
Partial Reversal of Tissue Calcification and Extension of Life Span following Ammonium Nitrate Treatment of Klotho-Deficient Mice
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Basel, Switzerland: S. Karger AG
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Language
English
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Publisher
Basel, Switzerland: S. Karger AG
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Background/Aims: Klotho is required for the inhibitory effect of FGF23 on 1,25(OH) 2 D 3 formation and Klotho-hypomorphic mice (kl/kl) suffer from severe tissue calcification due to excessive 1,25(OH) 2 D 3 formation with subsequent increase of Ca 2+ and phosphate concentrations and stimulation of osteogenic signaling. The excessive tissue calcific...
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Partial Reversal of Tissue Calcification and Extension of Life Span following Ammonium Nitrate Treatment of Klotho-Deficient Mice
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TN_cdi_doaj_primary_oai_doaj_org_article_914efc96f1e04c6ab4b77a95b265d290
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_914efc96f1e04c6ab4b77a95b265d290
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ISSN
1420-4096
E-ISSN
1423-0143
DOI
10.1159/000443411
