Novel regulators of PrPC biosynthesis revealed by genome-wide RNA interference
Novel regulators of PrPC biosynthesis revealed by genome-wide RNA interference
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Publisher
Public Library of Science (PLoS)
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Language
English
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Publisher
Public Library of Science (PLoS)
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Contents
The cellular prion protein PrPC is necessary for prion replication, and its reduction greatly increases life expectancy in animal models of prion infection. Hence the factors controlling the levels of PrPC may represent therapeutic targets against human prion diseases. Here we performed an arrayed whole-transcriptome RNA interference screen to iden...
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Full title
Novel regulators of PrPC biosynthesis revealed by genome-wide RNA interference
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TN_cdi_doaj_primary_oai_doaj_org_article_9152f0d3e0c7477f98a6de46bbe46854
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_9152f0d3e0c7477f98a6de46bbe46854
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ISSN
1553-7366
E-ISSN
1553-7374
DOI
10.1371/journal.ppat.1010013
