Measuring the iron content of dopaminergic neurons in substantia nigra with MRI relaxometry
Measuring the iron content of dopaminergic neurons in substantia nigra with MRI relaxometry
About this item
Full title
Author / Creator
Brammerloh, Malte , Morawski, Markus , Friedrich, Isabel , Reinert, Tilo , Lange, Charlotte , Pelicon, Primož , Vavpetič, Primož , Jankuhn, Steffen , Jäger, Carsten , Alkemade, Anneke , Balesar, Rawien , Pine, Kerrin , Gavriilidis, Filippos , Trampel, Robert , Reimer, Enrico , Arendt, Thomas , Weiskopf, Nikolaus and Kirilina, Evgeniya
Publisher
Amsterdam: Elsevier Inc
Journal title
Language
English
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Publication information
Publisher
Amsterdam: Elsevier Inc
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More information
Scope and Contents
Contents
•Dopaminergic neurons dominate effective transverse relaxation in nigrosome 1.•Ion beam microscopy reveals highest iron concentrations in dopaminergic neurons.•Developed biophysical model links MRI parameters to cellular iron content.•Ferritin- and neuromelanin-bound iron impact MRI parameters differently.•Quantitative MRI provides a potential biom...
Alternative Titles
Full title
Measuring the iron content of dopaminergic neurons in substantia nigra with MRI relaxometry
Authors, Artists and Contributors
Author / Creator
Morawski, Markus
Friedrich, Isabel
Reinert, Tilo
Lange, Charlotte
Pelicon, Primož
Vavpetič, Primož
Jankuhn, Steffen
Jäger, Carsten
Alkemade, Anneke
Balesar, Rawien
Pine, Kerrin
Gavriilidis, Filippos
Trampel, Robert
Reimer, Enrico
Arendt, Thomas
Weiskopf, Nikolaus
Kirilina, Evgeniya
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_924020a0d268449c83f36df87856f251
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_924020a0d268449c83f36df87856f251
Other Identifiers
ISSN
1053-8119
E-ISSN
1095-9572
DOI
10.1016/j.neuroimage.2021.118255
