The APOE isoforms differentially shape the transcriptomic and epigenomic landscapes of human microgl...
The APOE isoforms differentially shape the transcriptomic and epigenomic landscapes of human microglia xenografted into a mouse model of Alzheimer’s disease
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London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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Microglia play a key role in the response to amyloid beta in Alzheimer’s disease (AD). In this context, the major transcriptional response of microglia is the upregulation of
APOE
, the strongest late-onset AD risk gene. Of its three isoforms, APOE2 is thought to be protective, while APOE4 increases AD risk. We hypothesised that the isoforms...
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The APOE isoforms differentially shape the transcriptomic and epigenomic landscapes of human microglia xenografted into a mouse model of Alzheimer’s disease
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TN_cdi_doaj_primary_oai_doaj_org_article_9278e8fccb944ed185b13eaa25e09527
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_9278e8fccb944ed185b13eaa25e09527
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-025-60099-4
