Evaluation of the Effect of Loperamide on the Cardiac Repolarization Interval Using Exposure–Respons...
Evaluation of the Effect of Loperamide on the Cardiac Repolarization Interval Using Exposure–Response Analysis
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United States: John Wiley & Sons, Inc
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Language
English
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Publisher
United States: John Wiley & Sons, Inc
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ABSTRACT
This analysis assessed the relationship between the plasma concentrations of loperamide and its N‐desmethyl loperamide meta‐ bolite (M1) and the potential QT interval prolongation at therapeutic and supratherapeutic doses. The exposure–response analysis was performed using the data from healthy adults participating in a randomized, doub...
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Full title
Evaluation of the Effect of Loperamide on the Cardiac Repolarization Interval Using Exposure–Response Analysis
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TN_cdi_doaj_primary_oai_doaj_org_article_927e739b7f79490886925d5279b04f9b
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_927e739b7f79490886925d5279b04f9b
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ISSN
1752-8054,1752-8062
E-ISSN
1752-8062
DOI
10.1111/cts.70114
