Genome-wide CRISPR screening identifies PHF8 as an effective therapeutic target for KRAS- or BRAF-mu...
Genome-wide CRISPR screening identifies PHF8 as an effective therapeutic target for KRAS- or BRAF-mutant colorectal cancers
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Author / Creator
Liu, Zhao , Li, Yiqi , Wang, Simeng , Wang, Yubo , Sui, Mengjun , Liu, Jiaxin , Chen, Pu , Wang, Jianling , Zhang, Yuchen , Dang, Chengxue and Hou, Peng
Publisher
England: BioMed Central Ltd
Journal title
Language
English
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Publication information
Publisher
England: BioMed Central Ltd
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Scope and Contents
Contents
Mutations in KRAS and BRAF genes are prevalent in colorectal cancer (CRC), which strikingly promote tumorigenesis and lead to poor response to a variety of treatments including immunotherapy by activating the MAPK/ERK pathway. Thus, there is an urgent need to discover effective therapeutic targets and strategies.
CRISPR-Cas9 lentiviral knockout...
Alternative Titles
Full title
Genome-wide CRISPR screening identifies PHF8 as an effective therapeutic target for KRAS- or BRAF-mutant colorectal cancers
Authors, Artists and Contributors
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Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_93467054d8df49d5b9c35de940f6ed0d
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_93467054d8df49d5b9c35de940f6ed0d
Other Identifiers
ISSN
1756-9966,0392-9078
E-ISSN
1756-9966
DOI
10.1186/s13046-025-03338-2
