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Expression of the human molecular chaperone domain Bri2 BRICHOS on a gram per liter scale with an E....

Expression of the human molecular chaperone domain Bri2 BRICHOS on a gram per liter scale with an E....

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_9356cc4a12024f07b5234ce2a8a1ccd4

Expression of the human molecular chaperone domain Bri2 BRICHOS on a gram per liter scale with an E. coli fed-batch culture

About this item

Full title

Expression of the human molecular chaperone domain Bri2 BRICHOS on a gram per liter scale with an E. coli fed-batch culture

Publisher

London: BioMed Central Ltd

Journal title

Microbial cell factories, 2021-07, Vol.20 (1), p.1-150, Article 150

Language

English

Formats

Publication information

Publisher

London: BioMed Central Ltd

More information

Scope and Contents

Contents

The human Bri2 BRICHOS domain inhibits amyloid formation and toxicity and could be used as a therapeutic agent against amyloid diseases. For translation into clinical use, large quantities of correctly folded recombinant human (rh) Bri2 BRICHOS are required. To increase the expression and solubility levels of rh Bri2 BRICHOS it was fused to NT*, a...

Alternative Titles

Full title

Expression of the human molecular chaperone domain Bri2 BRICHOS on a gram per liter scale with an E. coli fed-batch culture

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_doaj_primary_oai_doaj_org_article_9356cc4a12024f07b5234ce2a8a1ccd4

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_9356cc4a12024f07b5234ce2a8a1ccd4

Other Identifiers

ISSN

1475-2859

E-ISSN

1475-2859

DOI

10.1186/s12934-021-01638-8

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