Type I interferons affect the metabolic fitness of CD8+ T cells from patients with systemic lupus er...
Type I interferons affect the metabolic fitness of CD8+ T cells from patients with systemic lupus erythematosus
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Publisher
London: Nature Publishing Group UK
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Language
English
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London: Nature Publishing Group UK
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Contents
The majority of patients with systemic lupus erythematosus (SLE) have high expression of type I IFN-stimulated genes. Mitochondrial abnormalities have also been reported, but the contribution of type I IFN exposure to these changes is unknown. Here, we show downregulation of mitochondria-derived genes and mitochondria-associated metabolic pathways...
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Full title
Type I interferons affect the metabolic fitness of CD8+ T cells from patients with systemic lupus erythematosus
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TN_cdi_doaj_primary_oai_doaj_org_article_956b2c52bede4e939180a254c3701f31
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_956b2c52bede4e939180a254c3701f31
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-021-22312-y
