Identification of Siglec-1 null individuals infected with HIV-1
Identification of Siglec-1 null individuals infected with HIV-1
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Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publisher
London: Nature Publishing Group UK
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Scope and Contents
Contents
Siglec-1/CD169 is a myeloid-cell surface receptor critical for HIV-1 capture and infection of bystander target cells. To dissect the role of
SIGLEC1 in natura
, we scan a large population genetic database and identify a loss-of-function variant (Glu88Ter) that is found in ∼1% of healthy people. Exome analysis and direct genotyping of 4,233 HI...
Alternative Titles
Full title
Identification of Siglec-1 null individuals infected with HIV-1
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TN_cdi_doaj_primary_oai_doaj_org_article_959f141fdeb24fdea52d8605fca12220
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_959f141fdeb24fdea52d8605fca12220
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/ncomms12412
