Combining genotypes and T cell receptor distributions to infer genetic loci determining V(D)J recomb...
Combining genotypes and T cell receptor distributions to infer genetic loci determining V(D)J recombination probabilities
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Publisher
England: eLife Sciences Publications Ltd
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Language
English
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Publisher
England: eLife Sciences Publications Ltd
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Contents
Every T cell receptor (TCR) repertoire is shaped by a complex probabilistic tangle of genetically determined biases and immune exposures. T cells combine a random V(D)J recombination process with a selection process to generate highly diverse and functional TCRs. The extent to which an individual’s genetic background is associated with their result...
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Full title
Combining genotypes and T cell receptor distributions to infer genetic loci determining V(D)J recombination probabilities
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TN_cdi_doaj_primary_oai_doaj_org_article_95bf64a4fda74d50b1793c5c3f136e61
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_95bf64a4fda74d50b1793c5c3f136e61
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ISSN
2050-084X
E-ISSN
2050-084X
DOI
10.7554/eLife.73475
