Oligomerized CARD16 promotes caspase-1 assembly and IL-1β processing
Oligomerized CARD16 promotes caspase-1 assembly and IL-1β processing
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Publisher
England: Elsevier B.V
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Language
English
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Publisher
England: Elsevier B.V
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Contents
•CARD16 is the most abundant CARD-only protein in hematopoietic cells.•Unlike CARD17, CARD16 oligomerizes to form a filament-like structure.•The filament-like structure formed by CARD16 promotes caspase 1 (CASP1) assembly.•CASP1-dependent IL-1β processing is enhanced by CARD16.•CARD16 colocalizes in ASC-speck by interacting with ASC.
Increasing...
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Full title
Oligomerized CARD16 promotes caspase-1 assembly and IL-1β processing
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TN_cdi_doaj_primary_oai_doaj_org_article_95e95b4fde7c4e91830b0160ad884702
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_95e95b4fde7c4e91830b0160ad884702
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ISSN
2211-5463
E-ISSN
2211-5463
DOI
10.1016/j.fob.2015.04.011
