Sodium permeable and “hypersensitive” TREK‐1 channels cause ventricular tachycardia
Sodium permeable and “hypersensitive” TREK‐1 channels cause ventricular tachycardia
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Author / Creator
Decher, Niels , Ortiz‐Bonnin, Beatriz , Friedrich, Corinna , Schewe, Marcus , Kiper, Aytug K , Rinné, Susanne , Seemann, Gunnar , Peyronnet, Rémi , Zumhagen, Sven , Bustos, Daniel , Kockskämper, Jens , Kohl, Peter , Just, Steffen , González, Wendy , Baukrowitz, Thomas , Stallmeyer, Birgit and Schulze‐Bahr, Eric
Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Contents
In a patient with right ventricular outflow tract (RVOT) tachycardia, we identified a heterozygous point mutation in the selectivity filter of the stretch‐activated K
2P
potassium channel TREK‐1 (
KCNK2
or K
2P
2.1). This mutation introduces abnormal sodium permeability to TREK‐1. In addition, mutant channels exhibit a hypersensit...
Alternative Titles
Full title
Sodium permeable and “hypersensitive” TREK‐1 channels cause ventricular tachycardia
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TN_cdi_doaj_primary_oai_doaj_org_article_9640f01ff7df45b1a9d350a18cebee9f
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_9640f01ff7df45b1a9d350a18cebee9f
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ISSN
1757-4676
E-ISSN
1757-4684
DOI
10.15252/emmm.201606690
