GDAP1 loss of function inhibits the mitochondrial pyruvate dehydrogenase complex by altering the act...
GDAP1 loss of function inhibits the mitochondrial pyruvate dehydrogenase complex by altering the actin cytoskeleton
About this item
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Author / Creator
Wolf, Christina , Pouya, Alireza , Bitar, Sara , Pfeiffer, Annika , Bueno, Diones , Rojas-Charry, Liliana , Arndt, Sabine , Gomez-Zepeda, David , Tenzer, Stefan , Bello, Federica Dal , Vianello, Caterina , Ritz, Sandra , Schwirz, Jonas , Dobrindt, Kristina , Peitz, Michael , Hanschmann, Eva-Maria , Mencke, Pauline , Boussaad, Ibrahim , Silies, Marion , Brüstle, Oliver , Giacomello, Marta , Krüger, Rejko and Methner, Axel
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publication information
Publisher
London: Nature Publishing Group UK
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More information
Scope and Contents
Contents
Charcot-Marie-Tooth (CMT) disease 4A is an autosomal-recessive polyneuropathy caused by mutations of ganglioside-induced differentiation-associated protein 1 (GDAP1), a putative glutathione transferase, which affects mitochondrial shape and alters cellular Ca
2+
homeostasis. Here, we identify the underlying mechanism. We found that patient-de...
Alternative Titles
Full title
GDAP1 loss of function inhibits the mitochondrial pyruvate dehydrogenase complex by altering the actin cytoskeleton
Authors, Artists and Contributors
Author / Creator
Pouya, Alireza
Bitar, Sara
Pfeiffer, Annika
Bueno, Diones
Rojas-Charry, Liliana
Arndt, Sabine
Gomez-Zepeda, David
Tenzer, Stefan
Bello, Federica Dal
Vianello, Caterina
Ritz, Sandra
Schwirz, Jonas
Dobrindt, Kristina
Peitz, Michael
Hanschmann, Eva-Maria
Mencke, Pauline
Boussaad, Ibrahim
Silies, Marion
Brüstle, Oliver
Giacomello, Marta
Krüger, Rejko
Methner, Axel
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_9641c18a790e4040bf3d22838d1e06f0
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_9641c18a790e4040bf3d22838d1e06f0
Other Identifiers
ISSN
2399-3642
E-ISSN
2399-3642
DOI
10.1038/s42003-022-03487-6
