Gating the pore of the calcium-activated chloride channel TMEM16A
Gating the pore of the calcium-activated chloride channel TMEM16A
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London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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The binding of cytoplasmic Ca
2+
to the anion-selective channel TMEM16A triggers a conformational change around its binding site that is coupled to the release of a gate at the constricted neck of an hourglass-shaped pore. By combining mutagenesis, electrophysiology, and cryo-electron microscopy, we identified three hydrophobic residues at th...
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Full title
Gating the pore of the calcium-activated chloride channel TMEM16A
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TN_cdi_doaj_primary_oai_doaj_org_article_9692a1f9cb0b436287d7a34b62620d89
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_9692a1f9cb0b436287d7a34b62620d89
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-020-20787-9
