Unraveling the Mechanism of Epichaperome Modulation by Zelavespib: Biochemical Insights on Target Oc...
Unraveling the Mechanism of Epichaperome Modulation by Zelavespib: Biochemical Insights on Target Occupancy and Extended Residence Time at the Site of Action
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Switzerland: MDPI AG
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Language
English
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Publisher
Switzerland: MDPI AG
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Drugs with a long residence time at their target sites are often more efficacious in disease treatment. The mechanism, however, behind prolonged retention at the site of action is often difficult to understand for non-covalent agents. In this context, we focus on epichaperome agents, such as zelavespib and icapamespib, which maintain target binding...
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Unraveling the Mechanism of Epichaperome Modulation by Zelavespib: Biochemical Insights on Target Occupancy and Extended Residence Time at the Site of Action
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TN_cdi_doaj_primary_oai_doaj_org_article_969e67720f1d409abb4c4efbd6be63ea
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_969e67720f1d409abb4c4efbd6be63ea
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ISSN
2227-9059
E-ISSN
2227-9059
DOI
10.3390/biomedicines11102599
