ERK signaling controls productive HIF‐1 binding to chromatin and cancer cell adaptation to hypoxia t...
ERK signaling controls productive HIF‐1 binding to chromatin and cancer cell adaptation to hypoxia through HIF‐1α interaction with NPM1
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United States: John Wiley & Sons, Inc
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Language
English
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Publisher
United States: John Wiley & Sons, Inc
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The hypoxia‐inducible factor HIF‐1 is essential for oxygen homeostasis. Despite its well‐understood oxygen‐dependent expression, regulation of its transcriptional activity remains unclear. We show that phosphorylation by extracellular signal‐regulated kinases1/2 (ERK1/2), in addition to promoting HIF‐1α nuclear accumulation, also enhances its inter...
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ERK signaling controls productive HIF‐1 binding to chromatin and cancer cell adaptation to hypoxia through HIF‐1α interaction with NPM1
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TN_cdi_doaj_primary_oai_doaj_org_article_96b5fdc018014ecb9f0b7ff7a70f7dfc
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_96b5fdc018014ecb9f0b7ff7a70f7dfc
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ISSN
1574-7891
E-ISSN
1878-0261
DOI
10.1002/1878-0261.13080
