Phase 1 dose-escalation trial evaluating a group 2 influenza hemagglutinin stabilized stem nanoparti...
Phase 1 dose-escalation trial evaluating a group 2 influenza hemagglutinin stabilized stem nanoparticle vaccine
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Author / Creator
The VRC 323 study team , VRC 323 study team , Casazza, Joseph P. , Hofstetter, Amelia R. , Costner, Pamela J. M. , Holman, LaSonji A. , Hendel, Cynthia S. , Widge, Alicia T. , Wu, Richard L. , Whalen, William R. , Cunningham, Jennifer , Arthur, Anita , Wang, Xiaolin , Ola, Abidemi , Saunders, Jamie , Mendoza, Floreliz , Novik, Laura , Burgos Florez, Maria C. , Ortega-Villa, Ana M. , Apte, Preeti J. , Strom, Larisa , Wang, Lu , Imam, Marjaan , Basappa, Manjula , Naisan, Mursal , Castro, Mike , Trost, Jessica F. , Narpala, Sandeep R. , Vanderven, Hillary A. , Yamshchikov, Galina V. , Berkowitz, Nina M. , Gordon, Ingelise J. , Plummer, Sarah H. , Wycuff, Diane L. , Vazquez, Sandra , Gillespie, Rebecca A. , Creanga, Adrian , Adams, William C. , Carlton, Kevin , Gall, Jason G. , McDermott, Adrian B. , Serebryannyy, Leonid A. , Houser, Katherine V. , Koup, Richard A. , Graham, Barney S. , Ledgerwood, Julie E. , Mascola, John R. , Pierson, Theodore C. , Andrews, Sarah F. , Kanekiyo, Masaru and Dropulic, Lesia K.
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publication information
Publisher
London: Nature Publishing Group UK
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More information
Scope and Contents
Contents
The relative conservation of the influenza hemagglutinin (HA) stem compared to that of the immunodominant HA head makes the HA stem an attractive target for broadly protective influenza vaccines. Here we report the first-in-human, dose-escalation, open-label trial (NCT04579250) evaluating an unadjuvanted group 2 stabilized stem ferritin nanoparticl...
Alternative Titles
Full title
Phase 1 dose-escalation trial evaluating a group 2 influenza hemagglutinin stabilized stem nanoparticle vaccine
Authors, Artists and Contributors
Author / Creator
VRC 323 study team
Casazza, Joseph P.
Hofstetter, Amelia R.
Costner, Pamela J. M.
Holman, LaSonji A.
Hendel, Cynthia S.
Widge, Alicia T.
Wu, Richard L.
Whalen, William R.
Cunningham, Jennifer
Arthur, Anita
Wang, Xiaolin
Ola, Abidemi
Saunders, Jamie
Mendoza, Floreliz
Novik, Laura
Burgos Florez, Maria C.
Ortega-Villa, Ana M.
Apte, Preeti J.
Strom, Larisa
Wang, Lu
Imam, Marjaan
Basappa, Manjula
Naisan, Mursal
Castro, Mike
Trost, Jessica F.
Narpala, Sandeep R.
Vanderven, Hillary A.
Yamshchikov, Galina V.
Berkowitz, Nina M.
Gordon, Ingelise J.
Plummer, Sarah H.
Wycuff, Diane L.
Vazquez, Sandra
Gillespie, Rebecca A.
Creanga, Adrian
Adams, William C.
Carlton, Kevin
Gall, Jason G.
McDermott, Adrian B.
Serebryannyy, Leonid A.
Houser, Katherine V.
Koup, Richard A.
Graham, Barney S.
Ledgerwood, Julie E.
Mascola, John R.
Pierson, Theodore C.
Andrews, Sarah F.
Kanekiyo, Masaru
Dropulic, Lesia K.
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_96bea20f4a6e46d8a78a3f7c6943f262
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_96bea20f4a6e46d8a78a3f7c6943f262
Other Identifiers
ISSN
2059-0105
E-ISSN
2059-0105
DOI
10.1038/s41541-024-00959-0
