LSD1 protects against hippocampal and cortical neurodegeneration
LSD1 protects against hippocampal and cortical neurodegeneration
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London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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To investigate the mechanisms that maintain differentiated cells, here we inducibly delete the histone demethylase LSD1/KDM1A in adult mice. Loss of LSD1 leads to paralysis, along with widespread hippocampus and cortex neurodegeneration, and learning and memory defects. We focus on the hippocampus neuronal cell death, as well as the potential link...
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LSD1 protects against hippocampal and cortical neurodegeneration
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TN_cdi_doaj_primary_oai_doaj_org_article_975c9ba119ac4b22972a6cb8a6b32326
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_975c9ba119ac4b22972a6cb8a6b32326
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-017-00922-9
