mRNA therapy restores euglycemia and prevents liver tumors in murine model of glycogen storage disea...
mRNA therapy restores euglycemia and prevents liver tumors in murine model of glycogen storage disease
About this item
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Author / Creator
Cao, Jingsong , Choi, Minjung , Guadagnin, Eleonora , Soty, Maud , Silva, Marine , Verzieux, Vincent , Weisser, Edward , Markel, Arianna , Zhuo, Jenny , Liang, Shi , Yin, Ling , Frassetto, Andrea , Graham, Anne-Renee , Burke, Kristine , Ketova, Tatiana , Mihai, Cosmin , Zalinger, Zach , Levy, Becca , Besin, Gilles , Wolfrom, Meredith , Tran, Barbara , Tunkey, Christopher , Owen, Erik , Sarkis, Joe , Dousis, Athanasios , Presnyak, Vladimir , Pepin, Christopher , Zheng, Wei , Ci, Lei , Hard, Marjie , Miracco, Edward , Rice, Lisa , Nguyen, Vi , Zimmer, Mike , Rajarajacholan, Uma , Finn, Patrick F. , Mithieux, Gilles , Rajas, Fabienne , Martini, Paolo G. V. and Giangrande, Paloma H.
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
Formats
Publication information
Publisher
London: Nature Publishing Group UK
Subjects
More information
Scope and Contents
Contents
Glycogen Storage Disease 1a (GSD1a) is a rare, inherited metabolic disorder caused by deficiency of glucose 6-phosphatase (G6Pase-α). G6Pase-α is critical for maintaining interprandial euglycemia. GSD1a patients exhibit life-threatening hypoglycemia and long-term liver complications including hepatocellular adenomas (HCAs) and carcinomas (HCCs). Th...
Alternative Titles
Full title
mRNA therapy restores euglycemia and prevents liver tumors in murine model of glycogen storage disease
Authors, Artists and Contributors
Author / Creator
Choi, Minjung
Guadagnin, Eleonora
Soty, Maud
Silva, Marine
Verzieux, Vincent
Weisser, Edward
Markel, Arianna
Zhuo, Jenny
Liang, Shi
Yin, Ling
Frassetto, Andrea
Graham, Anne-Renee
Burke, Kristine
Ketova, Tatiana
Mihai, Cosmin
Zalinger, Zach
Levy, Becca
Besin, Gilles
Wolfrom, Meredith
Tran, Barbara
Tunkey, Christopher
Owen, Erik
Sarkis, Joe
Dousis, Athanasios
Presnyak, Vladimir
Pepin, Christopher
Zheng, Wei
Ci, Lei
Hard, Marjie
Miracco, Edward
Rice, Lisa
Nguyen, Vi
Zimmer, Mike
Rajarajacholan, Uma
Finn, Patrick F.
Mithieux, Gilles
Rajas, Fabienne
Martini, Paolo G. V.
Giangrande, Paloma H.
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_977236f43e9f4fb4a8b6a0322537f1cb
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_977236f43e9f4fb4a8b6a0322537f1cb
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-021-23318-2
