Intranasal Niosomal In Situ Gel as a Promising Approach for Enhancing Flibanserin Bioavailability an...
Intranasal Niosomal In Situ Gel as a Promising Approach for Enhancing Flibanserin Bioavailability and Brain Delivery: In Vitro Optimization and Ex Vivo / In Vivo Evaluation
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Switzerland: MDPI
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Language
English
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Switzerland: MDPI
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Flibanserin (FLB) is a multifunctional serotonergic agent that was recently approved by the FDA for the oral treatment of premenopausal women with hypoactive sexual desire disorder. FLB is a centrally acting drug that has a low oral bioavailability of 33% owing to its exposure to the hepatic first-pass effect, as well as its pH-dependent solubility...
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Full title
Intranasal Niosomal In Situ Gel as a Promising Approach for Enhancing Flibanserin Bioavailability and Brain Delivery: In Vitro Optimization and Ex Vivo / In Vivo Evaluation
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TN_cdi_doaj_primary_oai_doaj_org_article_9784df45f76740319c3bf62098faf01a
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_9784df45f76740319c3bf62098faf01a
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ISSN
1999-4923
E-ISSN
1999-4923
DOI
10.3390/pharmaceutics12060485
