Nuclear factor of activated T-cells, NFATC1, governs FLT3ITD-driven hematopoietic stem cell transfor...
Nuclear factor of activated T-cells, NFATC1, governs FLT3ITD-driven hematopoietic stem cell transformation and a poor prognosis in AML
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London: BioMed Central Ltd
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English
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London: BioMed Central Ltd
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Background Acute myeloid leukemia (AML) patients with a high allelic burden of an internal tandem duplication (ITD)-mutated FMS-like Tyrosine Kinase-3 (FLT3) have a dismal outcome. FLT3ITD triggers the proliferation of the quiescent hematopoietic stem cell (HSC) pool but fails to directly transform HSCs. While the inflammatory transcription factor...
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Nuclear factor of activated T-cells, NFATC1, governs FLT3ITD-driven hematopoietic stem cell transformation and a poor prognosis in AML
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TN_cdi_doaj_primary_oai_doaj_org_article_97def0ffa83a43c2b02da120ec5c2f94
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_97def0ffa83a43c2b02da120ec5c2f94
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1756-8722
E-ISSN
1756-8722
DOI
10.1186/s13045-019-0765-y
