Sensory innervation in porous endplates by Netrin-1 from osteoclasts mediates PGE2-induced spinal hy...
Sensory innervation in porous endplates by Netrin-1 from osteoclasts mediates PGE2-induced spinal hypersensitivity in mice
About this item
Full title
Author / Creator
Ni, Shuangfei , Ling, Zemin , Wang, Xiao , Cao, Yong , Wu, Tianding , Deng, Ruoxian , Crane, Janet L. , Skolasky, Richard , Demehri, Shadpour , Zhen, Gehua , Jain, Amit , Wu, Panfeng , Pan, Dayu , Hu, Bo , Lyu, Xiao , Li, Yusheng , Chen, Hao , Qi, Huabin , Guan, Yun , Dong, Xinzhong , Wan, Mei , Zou, Xuenong , Lu, Hongbin , Hu, Jianzhong and Cao, Xu
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
Formats
Publication information
Publisher
London: Nature Publishing Group UK
Subjects
More information
Scope and Contents
Contents
Spinal pain is a major clinical problem, however, its origins and underlying mechanisms remain unclear. Here we report that in mice, osteoclasts induce sensory innervation in the porous endplates which contributes to spinal hypersensitivity in mice. Sensory innervation of the porous areas of sclerotic endplates in mice was confirmed. Lumbar spine i...
Alternative Titles
Full title
Sensory innervation in porous endplates by Netrin-1 from osteoclasts mediates PGE2-induced spinal hypersensitivity in mice
Authors, Artists and Contributors
Author / Creator
Ling, Zemin
Wang, Xiao
Cao, Yong
Wu, Tianding
Deng, Ruoxian
Crane, Janet L.
Skolasky, Richard
Demehri, Shadpour
Zhen, Gehua
Jain, Amit
Wu, Panfeng
Pan, Dayu
Hu, Bo
Lyu, Xiao
Li, Yusheng
Chen, Hao
Qi, Huabin
Guan, Yun
Dong, Xinzhong
Wan, Mei
Zou, Xuenong
Lu, Hongbin
Hu, Jianzhong
Cao, Xu
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_98071ec5c6bf43b7abff3310ff804c58
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_98071ec5c6bf43b7abff3310ff804c58
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-019-13476-9
