Rationally engineered Troponin C modulates in vivo cardiac function and performance in health and di...
Rationally engineered Troponin C modulates in vivo cardiac function and performance in health and disease
About this item
Full title
Author / Creator
Shettigar, Vikram , Zhang, Bo , Little, Sean C. , Salhi, Hussam E. , Hansen, Brian J. , Li, Ning , Zhang, Jianchao , Roof, Steve R. , Ho, Hsiang-Ting , Brunello, Lucia , Lerch, Jessica K. , Weisleder, Noah , Fedorov, Vadim V. , Accornero, Federica , Rafael-Fortney, Jill A. , Gyorke, Sandor , Janssen, Paul M. L. , Biesiadecki, Brandon J. , Ziolo, Mark T. and Davis, Jonathan P.
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
Formats
Publication information
Publisher
London: Nature Publishing Group UK
Subjects
More information
Scope and Contents
Contents
Treatment for heart disease, the leading cause of death in the world, has progressed little for several decades. Here we develop a protein engineering approach to directly tune in vivo cardiac contractility by tailoring the ability of the heart to respond to the Ca
2+
signal. Promisingly, our smartly formulated Ca
2+
-sensitizing TnC (L...
Alternative Titles
Full title
Rationally engineered Troponin C modulates in vivo cardiac function and performance in health and disease
Authors, Artists and Contributors
Author / Creator
Zhang, Bo
Little, Sean C.
Salhi, Hussam E.
Hansen, Brian J.
Li, Ning
Zhang, Jianchao
Roof, Steve R.
Ho, Hsiang-Ting
Brunello, Lucia
Lerch, Jessica K.
Weisleder, Noah
Fedorov, Vadim V.
Accornero, Federica
Rafael-Fortney, Jill A.
Gyorke, Sandor
Janssen, Paul M. L.
Biesiadecki, Brandon J.
Ziolo, Mark T.
Davis, Jonathan P.
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_9828c585327046c3b5306a0cb5e0d215
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_9828c585327046c3b5306a0cb5e0d215
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/ncomms10794
