CNTN5-/+or EHMT2-/+human iPSC-derived neurons from individuals with autism develop hyperactive neuro...
CNTN5-/+or EHMT2-/+human iPSC-derived neurons from individuals with autism develop hyperactive neuronal networks
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Author / Creator
Deneault, Eric , Faheem, Muhammad , White, Sean H , Rodrigues, Deivid C , Sun, Song , Wei, Wei , Piekna, Alina , Thompson, Tadeo , Howe, Jennifer L , Chalil, Leon , Kwan, Vickie , Walker, Susan , Pasceri, Peter , Roth, Frederick P , Yuen, Ryan KC , Singh, Karun K , Ellis, James and Scherer, Stephen W
Publisher
England: eLife Sciences Publications Ltd
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Language
English
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Publisher
England: eLife Sciences Publications Ltd
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Contents
Induced pluripotent stem cell (iPSC)-derived neurons are increasingly used to model Autism Spectrum Disorder (ASD), which is clinically and genetically heterogeneous. To study the complex relationship of penetrant and weaker polygenic risk variants to ASD, ‘isogenic’ iPSC-derived neurons are critical. We developed a set of procedures to control for...
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Full title
CNTN5-/+or EHMT2-/+human iPSC-derived neurons from individuals with autism develop hyperactive neuronal networks
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TN_cdi_doaj_primary_oai_doaj_org_article_985021e3ed064ed49d8ce14418bde9a2
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_985021e3ed064ed49d8ce14418bde9a2
Other Identifiers
ISSN
2050-084X
E-ISSN
2050-084X
DOI
10.7554/eLife.40092
