SARS-CoV-2 inhibits induction of the MHC class I pathway by targeting the STAT1-IRF1-NLRC5 axis
SARS-CoV-2 inhibits induction of the MHC class I pathway by targeting the STAT1-IRF1-NLRC5 axis
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London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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The MHC class I-mediated antigen presentation pathway plays a critical role in antiviral immunity. Here we show that the MHC class I pathway is targeted by SARS-CoV-2. Analysis of the gene expression profile from COVID-19 patients as well as SARS-CoV-2 infected epithelial cell lines reveals that the induction of the MHC class I pathway is inhibited...
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SARS-CoV-2 inhibits induction of the MHC class I pathway by targeting the STAT1-IRF1-NLRC5 axis
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TN_cdi_doaj_primary_oai_doaj_org_article_985ec8dc38ab4bd98cffc38c5682e3e9
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_985ec8dc38ab4bd98cffc38c5682e3e9
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-021-26910-8
