Inflammation produces catecholamine resistance in obesity via activation of PDE3B by the protein kin...
Inflammation produces catecholamine resistance in obesity via activation of PDE3B by the protein kinases IKKε and TBK1
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England: eLife Sciences Publications Ltd
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English
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England: eLife Sciences Publications Ltd
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Obesity produces a chronic inflammatory state involving the NFκB pathway, resulting in persistent elevation of the noncanonical IκB kinases IKKε and TBK1. In this study, we report that these kinases attenuate β-adrenergic signaling in white adipose tissue. Treatment of 3T3-L1 adipocytes with specific inhibitors of these kinases restored β-adrenergi...
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Inflammation produces catecholamine resistance in obesity via activation of PDE3B by the protein kinases IKKε and TBK1
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TN_cdi_doaj_primary_oai_doaj_org_article_98634cc3740a496c95b305f3ae070aec
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_98634cc3740a496c95b305f3ae070aec
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2050-084X
E-ISSN
2050-084X
DOI
10.7554/eLife.01119
