Use of signals of positive and negative selection to distinguish cancer genes and passenger genes
Use of signals of positive and negative selection to distinguish cancer genes and passenger genes
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Publisher
England: eLife Science Publications, Ltd
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Language
English
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England: eLife Science Publications, Ltd
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Contents
A major goal of cancer genomics is to identify all genes that play critical roles in carcinogenesis. Most approaches focused on genes positively selected for mutations that drive carcinogenesis and neglected the role of negative selection. Some studies have actually concluded that negative selection has no role in cancer evolution. We have re-exami...
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Full title
Use of signals of positive and negative selection to distinguish cancer genes and passenger genes
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TN_cdi_doaj_primary_oai_doaj_org_article_9873b379f6844defa777b01f1b4523b9
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_9873b379f6844defa777b01f1b4523b9
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ISSN
2050-084X
E-ISSN
2050-084X
DOI
10.7554/eLife.59629
