Carprofen alleviates Alzheimer-like phenotypes of 5XFAD transgenic mice by targeting the pathologica...
Carprofen alleviates Alzheimer-like phenotypes of 5XFAD transgenic mice by targeting the pathological hallmarks induced by amyloid-β aggregation
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London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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Alzheimer’s disease (AD) is characterized by misfolding, oligomerization, and accumulation of amyloid-β (Aβ) peptides in the brain. Aβ monomers transform into Aβ oligomers, which are toxic species, inducing tau hyperphosphorylation and the downstream effects on microglia and astrocytes, triggering synaptic and cognitive dysfunctions. The oligomers...
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Carprofen alleviates Alzheimer-like phenotypes of 5XFAD transgenic mice by targeting the pathological hallmarks induced by amyloid-β aggregation
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TN_cdi_doaj_primary_oai_doaj_org_article_988ddd39b0d24ca9a01eb94167a8e76b
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_988ddd39b0d24ca9a01eb94167a8e76b
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ISSN
2045-2322
E-ISSN
2045-2322
DOI
10.1038/s41598-023-36167-4
