Genetic, cellular, and structural characterization of the membrane potential-dependent cell-penetrat...
Genetic, cellular, and structural characterization of the membrane potential-dependent cell-penetrating peptide translocation pore
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England: eLife Sciences Publications Ltd
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English
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England: eLife Sciences Publications Ltd
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Cell-penetrating peptides (CPPs) allow intracellular delivery of bioactive cargo molecules. The mechanisms allowing CPPs to enter cells are ill-defined. Using a CRISPR/Cas9-based screening, we discovered that KCNQ5, KCNN4, and KCNK5 potassium channels positively modulate cationic CPP direct translocation into cells by decreasing the transmembrane p...
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Genetic, cellular, and structural characterization of the membrane potential-dependent cell-penetrating peptide translocation pore
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TN_cdi_doaj_primary_oai_doaj_org_article_98b234728cca409a8a4e7ab3072baed6
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_98b234728cca409a8a4e7ab3072baed6
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ISSN
2050-084X
E-ISSN
2050-084X
DOI
10.7554/eLife.69832
