The expression of four pyridoxal kinase (PDXK) human variants in Drosophila impacts on genome integr...
The expression of four pyridoxal kinase (PDXK) human variants in Drosophila impacts on genome integrity
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Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Contents
In eukaryotes, pyridoxal kinase (PDXK) acts in vitamin B
6
salvage pathway
to produce pyridoxal 5′-phosphate (PLP), the active form of the vitamin, which is implicated in numerous crucial metabolic reactions. In
Drosophila
, mutations in the
dPdxk
gene cause chromosome aberrations (CABs) and increase glucose content in larval h...
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Full title
The expression of four pyridoxal kinase (PDXK) human variants in Drosophila impacts on genome integrity
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TN_cdi_doaj_primary_oai_doaj_org_article_98cbd0cfb2e64e8c8b4f5fe2009a0e66
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_98cbd0cfb2e64e8c8b4f5fe2009a0e66
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ISSN
2045-2322
E-ISSN
2045-2322
DOI
10.1038/s41598-019-50673-4
