N (6)-substituted AMPs inhibit mammalian deoxynucleotide N-hydrolase DNPH1
N (6)-substituted AMPs inhibit mammalian deoxynucleotide N-hydrolase DNPH1
About this item
Full title
Author / Creator
Publisher
United States: Public Library of Science (PLoS)
Journal title
Language
English
Formats
Publication information
Publisher
United States: Public Library of Science (PLoS)
Subjects
More information
Scope and Contents
Contents
The gene dnph1 (or rcl) encodes a hydrolase that cleaves the 2'-deoxyribonucleoside 5'-monophosphate (dNMP) N-glycosidic bond to yield a free nucleobase and 2-deoxyribose 5-phosphate. Recently, the crystal structure of rat DNPH1, a potential target for anti-cancer therapies, suggested that various analogs of AMP may inhibit this enzyme. From this r...
Alternative Titles
Full title
N (6)-substituted AMPs inhibit mammalian deoxynucleotide N-hydrolase DNPH1
Authors, Artists and Contributors
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_98ea3adf9c284834a2d3cdcf4cbed64b
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_98ea3adf9c284834a2d3cdcf4cbed64b
Other Identifiers
E-ISSN
1932-6203
DOI
10.1371/journal.pone.0080755
