CAR exosomes derived from effector CAR-T cells have potent antitumour effects and low toxicity
CAR exosomes derived from effector CAR-T cells have potent antitumour effects and low toxicity
About this item
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Author / Creator
Fu, Wenyan , Lei, Changhai , Liu, Shuowu , Cui, Yingshu , Wang, Chuqi , Qian, Kewen , Li, Tian , Shen, Yafeng , Fan, Xiaoyan , Lin, Fangxing , Ding, Min , Pan, Mingzhu , Ye, Xuting , Yang, Yongji and Hu, Shi
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publication information
Publisher
London: Nature Publishing Group UK
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Scope and Contents
Contents
Genetically engineered T cells expressing a chimeric antigen receptor (CAR) are rapidly emerging a promising new treatment for haematological and non-haematological malignancies. CAR-T therapy can induce rapid and durable clinical responses but is associated with unique acute toxicities. Moreover, CAR-T cells are vulnerable to immunosuppressive mec...
Alternative Titles
Full title
CAR exosomes derived from effector CAR-T cells have potent antitumour effects and low toxicity
Authors, Artists and Contributors
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Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_9922d9f362cb422ca19401f860eaed83
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_9922d9f362cb422ca19401f860eaed83
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-019-12321-3
