SENP3 maintains the stability and function of regulatory T cells via BACH2 deSUMOylation
SENP3 maintains the stability and function of regulatory T cells via BACH2 deSUMOylation
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Author / Creator
Yu, Xiaoyan , Lao, Yimin , Teng, Xiao-Lu , Li, Song , Zhou, Yan , Wang, Feixiang , Guo, Xinwei , Deng, Siyu , Chang, Yuzhou , Wu, Xuefeng , Liu, Zhiduo , Chen, Lei , Lu, Li-Ming , Cheng, Jinke , Li, Bin , Su, Bing , Jiang, Jin , Li, Hua-Bing , Huang, Chuanxin , Yi, Jing and Zou, Qiang
Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Contents
Regulatory T (Treg) cells are essential for maintaining immune homeostasis and tolerance, but the mechanisms regulating the stability and function of Treg cells have not been fully elucidated. Here we show SUMO-specific protease 3 (SENP3) is a pivotal regulator of Treg cells that functions by controlling the SUMOylation and nuclear localization of...
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Full title
SENP3 maintains the stability and function of regulatory T cells via BACH2 deSUMOylation
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TN_cdi_doaj_primary_oai_doaj_org_article_99392c4923a841bda11bc7886d22d63c
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_99392c4923a841bda11bc7886d22d63c
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-018-05676-6
