Improved TMC1 gene therapy restores hearing and balance in mice with genetic inner ear disorders
Improved TMC1 gene therapy restores hearing and balance in mice with genetic inner ear disorders
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Publisher
London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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Fifty percent of inner ear disorders are caused by genetic mutations. To develop treatments for genetic inner ear disorders, we designed gene replacement therapies using synthetic adeno-associated viral vectors to deliver the coding sequence for Transmembrane Channel-Like (
Tmc
) 1 or 2 into sensory hair cells of mice with hearing and balance...
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Full title
Improved TMC1 gene therapy restores hearing and balance in mice with genetic inner ear disorders
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TN_cdi_doaj_primary_oai_doaj_org_article_998ee4b6a33b41c587d88c8b399215ea
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_998ee4b6a33b41c587d88c8b399215ea
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-018-08264-w
