A ribose-functionalized NAD+ with unexpected high activity and selectivity for protein poly-ADP-ribo...
A ribose-functionalized NAD+ with unexpected high activity and selectivity for protein poly-ADP-ribosylation
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London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Nicotinamide adenine dinucleotide (NAD
+
)-dependent ADP-ribosylation plays important roles in physiology and pathophysiology. It has been challenging to study this key type of enzymatic post-translational modification in particular for protein poly-ADP-ribosylation (PARylation). Here we explore chemical and chemoenzymatic synthesis of NAD
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A ribose-functionalized NAD+ with unexpected high activity and selectivity for protein poly-ADP-ribosylation
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TN_cdi_doaj_primary_oai_doaj_org_article_99a2c69f536344e0816740d2ed77a8f6
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_99a2c69f536344e0816740d2ed77a8f6
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-019-12215-4
