A human endothelial cell-based recycling assay for screening of FcRn targeted molecules
A human endothelial cell-based recycling assay for screening of FcRn targeted molecules
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Author / Creator
Grevys, Algirdas , Nilsen, Jeannette , Sand, Kine M. K. , Daba, Muluneh B. , Øynebråten, Inger , Bern, Malin , McAdam, Martin B. , Foss, Stian , Schlothauer, Tilman , Michaelsen, Terje E. , Christianson, Gregory J. , Roopenian, Derry C. , Blumberg, Richard S. , Sandlie, Inger and Andersen, Jan Terje
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publisher
London: Nature Publishing Group UK
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Scope and Contents
Contents
Albumin and IgG have remarkably long serum half-lives due to pH-dependent FcRn-mediated cellular recycling that rescues both ligands from intracellular degradation. Furthermore, increase in half-lives of IgG and albumin-based therapeutics has the potential to improve their efficacies, but there is a great need for robust methods for screening of re...
Alternative Titles
Full title
A human endothelial cell-based recycling assay for screening of FcRn targeted molecules
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Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_99bc76e2016a473a870d99a7c561cd47
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_99bc76e2016a473a870d99a7c561cd47
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-018-03061-x
