Structural basis of human ghrelin receptor signaling by ghrelin and the synthetic agonist ibutamoren
Structural basis of human ghrelin receptor signaling by ghrelin and the synthetic agonist ibutamoren
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London: Nature Publishing Group UK
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Language
English
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London: Nature Publishing Group UK
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The hunger hormone ghrelin activates the ghrelin receptor GHSR to stimulate food intake and growth hormone secretion and regulate reward signaling. Acylation of ghrelin at Ser3 is required for its agonistic action on GHSR. Synthetic agonists of GHSR are under clinical evaluation for disorders related to appetite and growth hormone dysregulation. He...
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Structural basis of human ghrelin receptor signaling by ghrelin and the synthetic agonist ibutamoren
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TN_cdi_doaj_primary_oai_doaj_org_article_99f1bc64dbea43bd809cc656f733f728
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_99f1bc64dbea43bd809cc656f733f728
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-021-26735-5
