Lymph node stromal cells constrain immunity via MHC class II self-antigen presentation
Lymph node stromal cells constrain immunity via MHC class II self-antigen presentation
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England: eLife Sciences Publications Ltd
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English
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England: eLife Sciences Publications Ltd
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Non-hematopoietic lymph node stromal cells shape immunity by inducing MHC-I-dependent deletion of self-reactive CD8+ T cells and MHC-II-dependent anergy of CD4+ T cells. In this study, we show that MHC-II expression on lymph node stromal cells is additionally required for homeostatic maintenance of regulatory T cells (Tregs) and maintenance of immu...
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Lymph node stromal cells constrain immunity via MHC class II self-antigen presentation
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TN_cdi_doaj_primary_oai_doaj_org_article_99fa18f315d64e2dadbbd38e868cabf0
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_99fa18f315d64e2dadbbd38e868cabf0
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ISSN
2050-084X
E-ISSN
2050-084X
DOI
10.7554/eLife.04433
