Genetic variation in GNB5 causes bradycardia by augmenting the cholinergic response via increased ac...
Genetic variation in GNB5 causes bradycardia by augmenting the cholinergic response via increased acetylcholine-activated potassium current ( I K,ACh)
About this item
Full title
Author / Creator
Veerman, Christiaan C. , Mengarelli, Isabella , Koopman, Charlotte D. , Wilders, Ronald , van Amersfoorth, Shirley C. , Bakker, Diane , Wolswinkel, Rianne , Hababa, Mariam , de Boer, Teun P. , Guan, Kaomei , Milnes, James , Lodder, Elisabeth M. , Bakkers, Jeroen , Verkerk, Arie O. and Bezzina, Connie R.
Publisher
England: The Company of Biologists Ltd
Journal title
Language
English
Formats
Publication information
Publisher
England: The Company of Biologists Ltd
Subjects
More information
Scope and Contents
Contents
Mutations in GNB5, encoding the G-protein β5 subunit (Gβ5), have recently been linked to a multisystem disorder that includes severe bradycardia. Here, we investigated the mechanism underlying bradycardia caused by the recessive p.S81L Gβ5 variant. Using CRISPR/Cas9-based targeting, we generated an isogenic series of human induced pluripotent stem...
Alternative Titles
Full title
Genetic variation in GNB5 causes bradycardia by augmenting the cholinergic response via increased acetylcholine-activated potassium current ( I K,ACh)
Authors, Artists and Contributors
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_9a0498e951bf479a8ce5b96fc11940df
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_9a0498e951bf479a8ce5b96fc11940df
Other Identifiers
ISSN
1754-8403
E-ISSN
1754-8411
DOI
10.1242/dmm.037994
