Cancer-associated fibroblasts-mediated ATF4 expression promotes malignancy and gemcitabine resistanc...
Cancer-associated fibroblasts-mediated ATF4 expression promotes malignancy and gemcitabine resistance in pancreatic cancer via the TGF-β1/SMAD2/3 pathway and ABCC1 transactivation
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Author / Creator
Wei, Lusheng , Lin, Qing , Lu, Yanan , Li, Guolin , Huang, Leyi , Fu, Zhiqiang , Chen, Rufu and Zhou, Quanbo
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publication information
Publisher
London: Nature Publishing Group UK
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Scope and Contents
Contents
Cancer-associated fibroblasts (CAFs) contribute to malignant progression and chemoresistance in pancreatic ductal adenocarcinoma (PDAC). However, little is known about the underlying mechanism. In this study, we investigated the potential role and mechanisms of activating transcription factor 4 (ATF4) in CAFs-induced malignancy and gemcitabine resi...
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Full title
Cancer-associated fibroblasts-mediated ATF4 expression promotes malignancy and gemcitabine resistance in pancreatic cancer via the TGF-β1/SMAD2/3 pathway and ABCC1 transactivation
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Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_9a5dec8d180c407885a2be16536f3a4b
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_9a5dec8d180c407885a2be16536f3a4b
Other Identifiers
ISSN
2041-4889
E-ISSN
2041-4889
DOI
10.1038/s41419-021-03574-2
