Metabolic flux from the Krebs cycle to glutamate transmission tunes a neural brake on seizure onset
Metabolic flux from the Krebs cycle to glutamate transmission tunes a neural brake on seizure onset
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Public Library of Science (PLoS)
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Language
English
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Publisher
Public Library of Science (PLoS)
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Kohlschütter-Tönz syndrome (KTS) manifests as neurological dysfunctions, including early-onset seizures. Mutations in the citrate transporter SLC13A5 are associated with KTS, yet their underlying mechanisms remain elusive. Here, we report that a Drosophila SLC13A5 homolog, I'm not dead yet (Indy), constitutes a neurometabolic pathway that suppresse...
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Full title
Metabolic flux from the Krebs cycle to glutamate transmission tunes a neural brake on seizure onset
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TN_cdi_doaj_primary_oai_doaj_org_article_9a656d4d0f794afb8c5a3b195cb8b474
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_9a656d4d0f794afb8c5a3b195cb8b474
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ISSN
1553-7390
E-ISSN
1553-7404
DOI
10.1371/journal.pgen.1009871
