Metamorphism in TDP-43 prion-like domain determines chaperone recognition
Metamorphism in TDP-43 prion-like domain determines chaperone recognition
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London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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The RNA binding protein TDP-43 forms cytoplasmic inclusions via its C-terminal prion-like domain in several neurodegenerative diseases. Aberrant TDP-43 aggregation arises upon phase de-mixing and transitions from liquid to solid states, following still unknown structural conversions which are primed by oxidative stress and chaperone inhibition. Des...
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Metamorphism in TDP-43 prion-like domain determines chaperone recognition
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TN_cdi_doaj_primary_oai_doaj_org_article_9a9166e33ea74700a35643c8927458e0
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_9a9166e33ea74700a35643c8927458e0
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-023-36023-z
