A toxic gain-of-function mechanism in C9orf72 ALS impairs the autophagy-lysosome pathway in neurons
A toxic gain-of-function mechanism in C9orf72 ALS impairs the autophagy-lysosome pathway in neurons
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England: BioMed Central Ltd
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English
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England: BioMed Central Ltd
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Motor neurons (MNs), which are primarily affected in amyotrophic lateral sclerosis (ALS), are a specialized type of neurons that are long and non-dividing. Given their unique structure, these cells heavily rely on transport of organelles along their axons and the process of autophagy to maintain their cellular homeostasis. It has been shown that di...
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Full title
A toxic gain-of-function mechanism in C9orf72 ALS impairs the autophagy-lysosome pathway in neurons
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TN_cdi_doaj_primary_oai_doaj_org_article_9ab3bd4af14745a6a8e291ef412cedba
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_9ab3bd4af14745a6a8e291ef412cedba
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ISSN
2051-5960
E-ISSN
2051-5960
DOI
10.1186/s40478-023-01648-0
